Correlation of viral load as determined by real-time RT-PCR and clinical characteristics of respiratory syncytial virus lower respiratory tract infections in early infancy.
J Clin Virol
; 41(1): 45-8, 2008 Jan.
Article
en En
| MEDLINE
| ID: mdl-18082444
ABSTRACT
BACKGROUND:
In infants hospitalized for a lower respiratory tract infection (RTI) caused by respiratory syncytial virus (RSV), the correlation between viral load (VL) and patient clinical characteristics remains to be defined.OBJECTIVES:
To define this correlation. STUDYDESIGN:
prospective study of 47 infants admitted to hospital in the period November 2006-May 2007 with a diagnosis of lower RTI. Nasopharyngeal aspirates (NPAs) were taken at admission, discharge, and at post-discharge control visits. VL was quantified by real-time RT-PCR for RSV subgroups A and B.RESULTS:
Patients with bronchiolitis were compared with young patients with lower RTI other than bronchiolitis. Patients with bronchiolitis had a significantly lower age than patients with other syndromes, and a significantly longer duration of symptoms. Duration of hospitalization was not different in the two groups of patients, and was not related to RSV subgroup or viral coinfection. A sustained decrease in VL was observed in the general patient population between admission, discharge and post-discharge follow-up visits.CONCLUSIONS:
(i) patients with bronchiolitis were significantly younger than patients with other lower RTIs; (ii) symptom duration was significantly longer in patients with bronchiolitis; (iii) RSV VL significantly decreased between admission and discharge.
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Banco de datos:
MEDLINE
Asunto principal:
Virus Sincitiales Respiratorios
/
Infecciones del Sistema Respiratorio
/
Infecciones por Virus Sincitial Respiratorio
Tipo de estudio:
Observational_studies
Límite:
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Clin Virol
Asunto de la revista:
VIROLOGIA
Año:
2008
Tipo del documento:
Article