Angiotensin II--AT1 receptor antagonists: design, synthesis and evaluation of substituted carboxamido benzimidazole derivatives.
Eur J Med Chem
; 43(9): 1808-12, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18158200
ABSTRACT
A series of 5-(alkyl and aryl)carboxamido benzimidazole derivatives had been designed, synthesized and evaluated for in vitro angiotensin II--AT1 receptor antagonism and in vivo antihypertensive activities. The pharmacological activities were inversely related to the size of alkyl and aryl substituents. It can be suggested that compounds with lower alkyl groups at 5-position of benzimidazole nucleus demonstrated potent antihypertensive activity.
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Banco de datos:
MEDLINE
Asunto principal:
Bencimidazoles
/
Diseño de Fármacos
/
Receptor de Angiotensina Tipo 1
/
Bloqueadores del Receptor Tipo 1 de Angiotensina II
Límite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Año:
2008
Tipo del documento:
Article
País de afiliación:
India