Changes in vitamin C and vitamin E during oxidative stress in myocardial reperfusion.
Indian J Physiol Pharmacol
; 51(2): 165-9, 2007.
Article
en En
| MEDLINE
| ID: mdl-18175661
ABSTRACT
Injury to the myocardial tissue due to ischemia and reperfusion occurs because of imbalance between the formation of oxidants and available antioxidants in the heart. Levels of vitamin C (ascorbic acid) and vitamin E (alpha--tocopherol) were evaluated in 52 patients of acute myocardial infarction (AMI) treated by streptokinase. They were further divided into reperfused group (39 patients) and non-reperfused group (13 patients). Twenty normal healthy subjects served as controls. Vitamin C and vitamin E were estimated in study group before and after thrombolytic therapy and in controls. Vitamin C levels were low in AMI cases as compared to controls (8.74 +/- 1.87 and 10.63 +/- 3.26 mg/L, respectively, P < 0.001). Trend of fall in vitamin C levels in the two study groups was not statistically significant. Vitamin E levels declined from 12.19 +/- 6.71 to 9.96 +/- 6.50 mg/L by 4 hours which was significant (P < 0.01) in the reperfused group, but the change in non-reperfused group (9.28 +/- 6.37 to 9.35 +/- 6.07 mg/dL by 4 hours) was non-significant. This is because of increased consumption of this antioxidant in suppressing the oxidative stress which occurs with reperfusion. Vitamin E can be proposed as a valid marker for reperfusion.
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Banco de datos:
MEDLINE
Asunto principal:
Ácido Ascórbico
/
Vitamina E
/
Daño por Reperfusión Miocárdica
/
Estrés Oxidativo
/
Infarto del Miocardio
Límite:
Humans
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Año:
2007
Tipo del documento:
Article