Indomethacin modulation of monocyte cytokine release following pelvic irradiation for cancer.
Eur J Cancer
; 27(5): 591-4, 1991.
Article
en En
| MEDLINE
| ID: mdl-1828968
ABSTRACT
Pelvic irradiation for urogenital cancer reduced monocyte release of tumour necrosis factor alpha (TNF-alpha). Addition of indomethacin to monocyte cultures increased TNF-alpha production after but not before irradiation. E. coli lipopolysaccharide (LPS) increased TNF-alpha release before as well as after radiation therapy and addition of indomethacin to LPS-stimulated monocytes further increased TNF-alpha production following radiotherapy. Spontaneous interleukin-1 (IL-1) release was increased in the cancer patients and was not significantly affected by radiation therapy. LPS increased IL-1 release before as well as after irradiation, but indomethacin did not further change IL-1 secretion. These findings suggest that prostaglandins differentially regulate TNF-alpha and IL-1 release. Administration of cyclo-oxygenase inhibitors during radiation therapy might increase TNF-alpha release in vivo and thereby enhance the host defence against tumours.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Monocitos
/
Indometacina
/
Lipopolisacáridos
/
Interleucina-1
/
Factor de Necrosis Tumoral alfa
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Cancer
Año:
1991
Tipo del documento:
Article
País de afiliación:
Suecia