Analytic bias among certified methods for the measurement of hemoglobin A1c: a cause for concern?
Am J Clin Pathol
; 129(4): 540-7, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-18343780
ABSTRACT
We studied the magnitude, significance, and origin of an analytic bias that emerged between our point-of-care (POC) and our central laboratory (CL) methods for the measurement of hemoglobin A1c (HbA1c) and evaluated the analytic accuracy of 7 commonly used HbA1c methods relative to the National Glycohemoglobin Standardization Program (NGSP) reference method. The POC and CL methods were compared by split-sample analysis of clinical specimens and time series analyses of the HbA1c results reported for a 33-month period. The relative accuracies of 7 HbA1c methods were evaluated using College of American Pathologists proficiency survey results. Long-term drifts in the CL- and POC-analyzed test results caused the median intermethod bias [(POC result)-(CL result)] to increase from -0.4% to -0.9% HbA1c. Systematic biases, drifts in analytic performance over time, and intermethod variability were frequently observed among the 7 NGSP-certified HbA1c methods. Intermethod variability is a potential source of inaccuracy whenever HbA1c results are interpreted relative to universal, fixed, clinical decision thresholds.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Control de Calidad
/
Análisis Químico de la Sangre
/
Hemoglobina Glucada
/
Laboratorios
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Clin Pathol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos