Crusade for iron: iron uptake in unicellular eukaryotes and its significance for virulence.
Trends Microbiol
; 16(6): 261-8, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18467097
ABSTRACT
The effective acquisition of iron is a pre-requisite for survival of all organisms, especially parasites that have a high iron requirement. In mammals, iron homeostasis is meticulously regulated; extracellular free iron is essentially unavailable and host iron availability has a crucial role in the host-pathogen relationship. Therefore, pathogens use specialized and effective mechanisms to acquire iron. In this review, we summarize the iron-uptake systems in eukaryotic unicellular organisms with particular focus on the pathogenic species Candida albicans, Tritrichomonas foetus, Trypanosoma brucei and Leishmania spp. We describe the diversity of their iron-uptake mechanisms and highlight the importance of the process for virulence.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trypanosoma brucei brucei
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Candida albicans
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Tritrichomonas foetus
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Hierro
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Leishmania
Límite:
Animals
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Humans
Idioma:
En
Revista:
Trends Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Australia