High prevalence of HFE gene mutations in hemodialysis patients.
Minerva Urol Nefrol
; 60(2): 81-4, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18500222
ABSTRACT
AIM:
Hemochromatosis (HH) was a common inherited disease characterized by iron overload. This disease is usually the result of mutations in the HLA-linked hemochromatosis gene (HFE). The aim of this study was to evaluate the frequency of HFE mutations in a group of Venetian hemodialysis patients.METHODS:
Sixty-one hemodialysis patients, 62 patients with laboratory findings suggestive for iron overload, 57 repeat blood donors were enrolled in the study. HFE mutations were detected by using a commercial strip assay.RESULTS:
In this study only H63D and C282Y mutations were observed. The overall prevalence of HFE mutations was 40.9% among hemodialysis patients, 30.6% among patients with laboratory findings of iron overload and 15.8% among blood donors.CONCLUSION:
A high prevalence of HFE mutation among hemodialysis patients was observed. Prevalence of HFE mutation in this group was 40.9%, significantly higher than results observed among blood donors (15.8%, P<0.005) or among patients with laboratory signs of iron overload (30.6%, P<0.01). These data are, at present inexplicable, and this results need further confirmation.
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Banco de datos:
MEDLINE
Asunto principal:
Antígenos de Histocompatibilidad Clase I
/
Diálisis Renal
/
Hemocromatosis
/
Proteínas de la Membrana
/
Mutación
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Minerva Urol Nefrol
Asunto de la revista:
NEFROLOGIA
/
UROLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia