Mixed tetraoxanes containing the acetone subunit as antimalarials.
Bioorg Med Chem
; 16(14): 7039-45, 2008 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-18550377
ABSTRACT
Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi-drug resistant TM91C235 strain. Amine 8 cured all mice at the dose of 160mg/kg/day, while the anilide 9 exhibited MCD
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tetraoxanos
/
Antimaláricos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2008
Tipo del documento:
Article