A case-control study of childhood brain tumors and fathers' hobbies: a Children's Oncology Group study.
Cancer Causes Control
; 19(10): 1201-7, 2008 Dec.
Article
en En
| MEDLINE
| ID: mdl-18560982
ABSTRACT
OBJECTIVE:
A comprehensive case-control study was conducted to evaluate parental risk factors for medulloblastoma (MB) and primitive neuroectodermal tumor (PNET). This analysis was conducted to evaluate associations between fathers' hobbies and risk of their children developing MB/PNET. The hobbies chosen for study were those with similar exposures as occupations associated with childhood cancers.METHODS:
Cases were 318 subjects under six years of age at diagnosis between 1991 and 1997 and registered with the Children's Cancer Group. An equal number of controls were selected through random digit dialing and individually matched to cases.RESULTS:
In multivariate analyses, a significant association was seen for lawn care with pesticides [during pregnancy odds ratio (OR) = 1.6, 95% confidence interval (CI) 1.0, 2.5; after birth OR = 1.8, 95% CI 1.2, 2.8] and a weak association was seen for stripping paint [during pregnancy OR = 1.4, 95% CI 0.8, 2.6; after birth OR = 1.4, 95% CI 0.7, 2.6].CONCLUSIONS:
This study suggests that household exposures from hobbies, particularly pesticides, may increase risk of MB/PNET in children; previous research has been mostly limited to occupational exposures.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Tumores Neuroectodérmicos Primitivos
/
Padre
/
Pasatiempos
/
Meduloblastoma
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cancer Causes Control
Asunto de la revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos