Characterizing multimode interaction in renal autoregulation.
Physiol Meas
; 29(8): 945-58, 2008 Aug.
Article
en En
| MEDLINE
| ID: mdl-18603665
ABSTRACT
The purpose of this paper is to demonstrate how modern statistical techniques of non-stationary time-series analysis can be used to characterize the mutual interaction among three coexisting rhythms in nephron pressure and flow regulation. Besides a relatively fast vasomotoric rhythm with a period of 5-8 s and a somewhat slower mode arising from an instability in the tubuloglomerular feedback mechanism, we also observe a very slow mode with a period of 100-200 s. Double-wavelet techniques are used to study how the very slow rhythm influences the two faster modes. In a broader perspective, the paper emphasizes the significance of complex dynamic phenomena in the normal and pathological function of physiological systems and discusses how simulation methods can help to understand the underlying biological mechanisms. At the present there is no causal explanation of the very slow mode. However, vascular oscillations with similar frequencies have been observed in other tissues.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Modelos Estadísticos
/
Homeostasis
/
Riñón
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Physiol Meas
Asunto de la revista:
BIOFISICA
/
ENGENHARIA BIOMEDICA
/
FISIOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Rusia