Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101.
Biochem Soc Trans
; 37(Pt 1): 204-7, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-19143632
ABSTRACT
Class E Vps (vacuolar protein sorting) proteins are components of the ESCRTs (endosomal sorting complexes required for transport) which are required for protein sorting at the early endosome. Most of these genes have been identified and genetically characterized in yeast. Recent genetic studies in Drosophila have revealed the phenotypic consequences of loss of vps function in multicellular organisms. In the present paper, we review these studies and discuss a mechanism which may explain how loss of the human Tsg101 (tumour susceptibility gene 101), a vps23 orthologue, causes tumours.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Endosomas
/
Factores de Transcripción
/
Complejos Multiproteicos
/
Proteínas de Unión al ADN
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Drosophila melanogaster
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos