Adrenomedullin and endothelin-1 are related to inflammation in chronic heart failure.
Inflamm Res
; 58(6): 298-305, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-19212702
ABSTRACT
BACKGROUND:
Adrenomedullin (ADM) and endothelin-1 (ET-1) are novel promising peptide biomarkers in chronic heart failure (CHF). According to recent studies among their pleiotropic effect they play roles in the regulation of inflammation. The aim of the study was to measure the above mentioned two vasoactive peptides in parallel in a well characterized population of patients with CHF, and study their associations with inflammatory markers. MATERIALS ANDMETHODS:
A total of 186 patients (138 male, 48 female) with <45% left ventricular ejection fraction (LVEF), and without acute inflammatory disease, were enrolled. Plasma midregional-proADM (MR-proADM) and C-terminal-proET-1 (CT-proET-1) were determined by a novel sandwich immunoluminometric assay.RESULTS:
Increased MR-proADM and CT-proET-1 plasma levels were measured in patients with severe CHF (NYHA III-IV) as compared to the group of NYHA I-II (p<0.0001). MR-proADM and CT-proET-1 levels showed significant negative correlation with serum albumin and prealbumin levels (pCONCLUSIONS:
Vasoregulation and inflammation may be connected in heart failure patients independently of the disease severity. The observed link may contribute to the understanding of the complex pathomechanism in CHF.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Disfunción Ventricular Izquierda
/
Endotelina-1
/
Adrenomedulina
/
Insuficiencia Cardíaca
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Inflamm Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Hungria