Highly enantioselective zinc/amino alcohol-catalyzed alkynylation of aldehydes.

Zhong, Jiang-Chun; Hou, Shi-Cong; Bian, Qing-Hua; Yin, Min-Min; Na, Ri-Song; Zheng, Bing; Li, Zhi-Yuan; Liu, Shang-Zhong; Wang, Min

Zhong, Jiang-Chun; Hou, Shi-Cong; Bian, Qing-Hua; Yin, Min-Min; Na, Ri-Song; Zheng, Bing; Li, Zhi-Yuan; Liu, Shang-Zhong; Wang, Min.

Afiliación

Zhong JC; Department of Applied Chemistry, China Agricultural University, Beijing, China.

Chemistry ; 15(13): 3069-71, 2009.

Article en En | MEDLINE | ID: mdl-19219869

RESUMEN

Meeting the challenge: The zinc/amino alcohol catalyzed enantioselective addition of terminal alkynes to aldehydes is effective with both phenylacetylene and methyl propiolate, leading to chiral secondary propargyl alcohols with very high enantioselectivity (see scheme).

Asunto(s)

Aldehídos/química; Alquinos/química; Amino Alcoholes/química; Propanoles/síntesis química; Zinc/química; Alquinos/síntesis química; Catálisis; Técnicas Químicas Combinatorias; Ciclopropanos/química; Modelos Químicos; Estructura Molecular; Estereoisomerismo

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Zinc / Propanoles / Aldehídos / Alquinos / Amino Alcoholes Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2009 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google