Hematopoietic growth factor mimetics: from concept to clinic.
Cytokine Growth Factor Rev
; 20(1): 87-94, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-19223217
ABSTRACT
Hematopoietic growth factor (HGF) mimetics offer a number of attractive advantages as therapeutic agents. Small chemical compounds, in particular, provide reduced cost and oral availability. As many of these mimetics are unrelated in structure to the normal cytokine the immunogenic response is not a significant issue. Isolation of small peptide agonists for erythropoietin (EPO) and thrombopoietin (TPO) receptors has been associated with significant translational challenges and here we summarize approaches used to achieve the potency and stability required for clinical utility. We also compare and contrast the initial screening approaches, and the translational and clinical issues associated with two recently approved TPO mimetics, romiplostim and the orally available eltrombopag. Finally we summarize the development and clinical findings for the EPO mimetic, Hematide, consider alternative approaches, and discuss the future potential for isolation of growth factor (GF) mimetics.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factores de Crecimiento de Célula Hematopoyética
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Australia