Synthesis and cytotoxicity of 2-cyano-28-hydroxy-lup-1-en-3-ones.
Bioorg Med Chem Lett
; 19(8): 2168-71, 2009 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-19286375
ABSTRACT
New A-ring modified betulin and dihydrobetulin derivatives possessing the 2-cyano-1-en-3-one moiety were prepared and tested for cytotoxicity in seven cancer cell lines. The most active agent 9a synthesized in this account was further demonstrated to induce apoptosis and to activate caspases in malignant melanoma cells.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Inhibidores de Crecimiento
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos