Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways.
J Neuroimmunol
; 211(1-2): 49-55, 2009 Jun 25.
Article
en En
| MEDLINE
| ID: mdl-19346009
ABSTRACT
USPIO-enhanced MRI allows non-invasive visualization of mononuclear cell infiltration into CNS lesions in MS and EAE. Herein, we show a distinct spatiotemporal pattern of CNS lesions that reveals the involvement of spino-olivocerebellar pathways in MOG-induced EAE rats using USPIO-enhanced MRI. Specifically, lesions of the inferior olives were observed primarily in the acute phase whereas lesions of cerebellum or spinal cord/brainstem were observed during the relapse phase. Further, behavioral deficits observed from these animals are consistent with the functional role of spino-olivocerebellar pathways in coordination and movement. Collectively, our results provide new insights into the pathophysiology of this animal model of MS.
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1
Banco de datos:
MEDLINE
Asunto principal:
Médula Espinal
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Encéfalo
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Imagen por Resonancia Magnética
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Encefalomielitis Autoinmune Experimental
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Vías Nerviosas
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos