Indobufen versus placebo in the prevention of restenosis after carotid endarterectomy: a double-blind pilot study.
J Int Med Res
; 19(3): 202-9, 1991.
Article
en En
| MEDLINE
| ID: mdl-1936509
ABSTRACT
A randomized clinical trial was undertaken to assess the efficacy of indobufen in inhibiting platelet adhesiveness in carotid thromboendarterectomy. The patients were treated under double-blind conditions with indobufen and with placebo, and were then assessed by means of scintigraphy with labelled platelets, ultrasonic tomography and angiography for a minimum follow-up period of 6 months. Haematological and clinical assessments were also performed. The results of the study suggest that platelet accumulation in carotid endarterectomy may be an early sign of restenosis; anti-aggregant treatment with indobufen carried out at an early stage prior to surgery inhibited platelet accumulation. The final result showed that anti-aggregant treatment had a positive influence on the short- and medium-term outcome of carotid endarterectomy.
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Banco de datos:
MEDLINE
Asunto principal:
Fenilbutiratos
/
Arteriopatías Oclusivas
/
Inhibidores de Agregación Plaquetaria
/
Enfermedades de las Arterias Carótidas
/
Endarterectomía
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Int Med Res
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia