Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure in spontaneously hypertensive rats.
Arch Pharm Res
; 32(3): 353-8, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-19387578
ABSTRACT
A combination of antihypertensive agents can better control blood pressure and reduce the number and severity of side effects than a monotherapy. Since both CCBs (calcium channel blockers) and ARBs (angiotensin II receptor type-1 blockers) are current and effective antihypertensive drugs, this study assessed the synergistic antihypertensive effects as well as the optimal combination ratio of these two drugs. Amlodipine (3 mg/kg) or losartan (30 mg/kg) alone or a combination of each drug at a ratio 110 and 120 was administered orally to spontaneously hypertensive rats (SHR). A four-week treatment of either 3 mg/kg amlodipine or 30 mg/kg losartan alone decreased the systolic blood pressure (SBP). However, their combination significantly lowered the SBP from the 3(rd) week, and there was a positive correlation between this reduction in blood pressure and the improvement in arterial endothelium-dependent relaxation. In addition, the combination therapy (120) decreased both the cardiac mass and left ventricular weight to a greater extent than with either amlodipine or losartan alone. The collagen content in the cardiac tissue was also significantly lower after the 4-week combination therapy (110). These results suggest that the combined use of amlodipine and losartan might be more effective in treating hypertension than a monotherapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vasodilatadores
/
Presión Sanguínea
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Bloqueadores de los Canales de Calcio
/
Amlodipino
/
Losartán
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Bloqueadores del Receptor Tipo 1 de Angiotensina II
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Hipertensión
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Antihipertensivos
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Pharm Res
Año:
2009
Tipo del documento:
Article