Shared and persistent asymptomatic cutaneous human papillomavirus infections in healthy skin.
J Med Virol
; 81(8): 1444-9, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-19551818
ABSTRACT
Cutaneous human papillomavirus (HPV) types are commonly found in normal skin, and some of them have been suspected to play a role in the development of non-melanoma skin cancer. This present study is divided into three sections, the aims of this study were to examine if certain HPV-types persist over time and if HPV-types are shared within families. From the first part of the study, swab samples from foreheads were collected for three longitudinal studies from one family with a newborn baby. Five specific HPV-types were isolated from the family with a newborn, with HPV-5 and FA67 being found at various time points and prevalence rates in all four members of the family. Part 2 consisted of a followed up study from two families with a 6 years interval. Six of the family members were found to have at least one of the HPV-types identified in the family 6 years earlier. Many of the HPV-types identified were shared within the families studied. Part 3 of this study involved weekly samples from four healthy females for 4 months. Among the four healthy individuals, 11%, 65%, and 56% of the weekly samples were HPV-DNA positive with one individual HPV-negative. All specimens were tested for HPV-DNA by PCR using the broad range HPV-type primer pair FAP59/64. The positive samples were HPV-type determined by cloning and sequencing. Specific cutaneous HPV-types persist over long periods of time in healthy skin in most individuals investigated and certain HPVs are shared between family members.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Papillomaviridae
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Piel
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Enfermedades Cutáneas Virales
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Infecciones por Papillomavirus
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Adult
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Child
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Child, preschool
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Female
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Humans
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Male
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Newborn
Idioma:
En
Revista:
J Med Virol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Australia