CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.
Cell
; 138(2): 271-85, 2009 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-19632178
ABSTRACT
Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis of normal, healthy cells. We find that mobilizing cytokines and inflammatory stimuli cause CD47 to be transiently upregulated on mouse hematopoietic stem cells (HSCs) and progenitors just prior to and during their migratory phase, and that the level of CD47 on these cells determines the probability that they are engulfed in vivo. CD47 is also constitutively upregulated on mouse and human myeloid leukemias, and overexpression of CD47 on a myeloid leukemia line increases its pathogenicity by allowing it to evade phagocytosis. We conclude that CD47 upregulation is an important mechanism that provides protection to normal HSCs during inflammation-mediated mobilization, and that leukemic progenitors co-opt this ability in order to evade macrophage killing.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fagocitosis
/
Células Madre Neoplásicas
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Células Madre Hematopoyéticas
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Antígeno CD47
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos