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Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-associated ophthalmopathy.
Khanna, Dinesh; Chong, Kelvin K L; Afifiyan, Nikoo F; Hwang, Catherine J; Lee, Diana K; Garneau, Helene Chokron; Goldberg, Robert A; Darwin, Christine H; Smith, Terry J; Douglas, Raymond S.
Afiliación
  • Khanna D; Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Ophthalmology ; 117(1): 133-139.e2, 2010 Jan.
Article en En | MEDLINE | ID: mdl-19818507
ABSTRACT

PURPOSE:

To study the effectiveness of anti-CD20 (rituximab [RTX]; Rituxan; Genentech, Inc., South San Francisco, CA) therapy in patients with severe, corticosteroid (CS)-resistant thyroid-associated ophthalmopathy (TAO).

DESIGN:

Retrospective, interventional case series.

PARTICIPANTS:

Six consecutive subjects with severe, progressive TAO unresponsive to CS.

METHODS:

Electronic medical record review of consecutive patients receiving RTX during the previous 18 months. Responses to therapy were graded using standard clinical assessment and flow cytometric analysis of peripheral lymphocytes. MAIN OUTCOME

MEASURES:

Clinical activity score (CAS), proptosis, strabismus, treatment side effects, and quantification of regulatory T cells.

RESULTS:

Six patients were studied. Systemic CS failed to alter clinical activity in all patients (mean CAS+/-standard deviation, 5.3+/-1.0 before vs. 5.5+/-0.8 during therapy for 7.5+/-6.4 months; P = 1.0). However, after RTX treatment, CAS improved from 5.5+/-0.8 to 1.3+/-0.5 at 2 months after treatment (P<0.03) and remained quiescent in all patients (CAS, 0.7+/-0.8; P<0.0001) at a mean follow-up of 6.2+/-4.5 months. Vision improved bilaterally in all 4 patients with dysthyroid optic neuropathy (DON). None of the 6 patients experienced disease relapse after RTX infusion, and proptosis remained stable (Hertel measurement, 24+/-3.7 mm before therapy and 23.6+/-3.7 mm after therapy; P = 0.17). The abundance of T regulatory cells, assessed in 1 patient, increased within 1 week of RTX and remained elevated at 18 months of follow-up.

CONCLUSIONS:

In progressive, CS-resistant TAO, rapid and sustained resolution of orbital inflammation and DON followed treatment with RTX. FINANCIAL DISCLOSURE(S) The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a Medicamentos / Oftalmopatía de Graves / Glucocorticoides / Factores Inmunológicos / Anticuerpos Monoclonales Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ophthalmology Año: 2010 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a Medicamentos / Oftalmopatía de Graves / Glucocorticoides / Factores Inmunológicos / Anticuerpos Monoclonales Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ophthalmology Año: 2010 Tipo del documento: Article País de afiliación: Estados Unidos