RIP4 is a target of multiple signal transduction pathways in keratinocytes: implications for epidermal differentiation and cutaneous wound repair.
Exp Cell Res
; 316(1): 126-37, 2010 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-19818768
ABSTRACT
Receptor interacting protein 4 (RIP4) is an important regulator of epidermal morphogenesis during embryonic development. We could previously show that expression of the rip4 gene is strongly downregulated in cutaneous wound repair, which might be initiated by a broad variety of growth factors and cytokines. Here, we demonstrate that in keratinocytes, rip4 expression is controlled by a multitude of different signal transduction pathways, such as the p38 mitogen-activated protein kinase (MAPK) and the nuclear factor kappa B (NF-kappaB) cascade, in a unique and specific manner. Furthermore, we show that the steroid dexamethasone abolishes the physiological rip4 downregulation after injury and might thus contribute to the phenotype of reduced and delayed wound reepithelialization seen in glucocorticoid-treated patients. As a whole, our data indicate that rip4 expression is regulated in a complex manner, which might have therapeutic implications.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Transducción de Señal
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Queratinocitos
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Diferenciación Celular
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Proteínas Serina-Treonina Quinasas
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Células Epidérmicas
Límite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
Exp Cell Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania