[TNFalpha blockers and infectious risk in rheumatoid arthritis]. / I farmaci biologici anti-TNFalpha e il rischio infettivo nell'artrite reumatoide.
Reumatismo
; 61(3): 165-73, 2009.
Article
en It
| MEDLINE
| ID: mdl-19888501
ABSTRACT
Patients suffering from rheumatoid arthritis have increased risk of infections when compared with general population. The risk depends directly from disease activity and severity. Furthermore, risk increases with aging, immunosuppressive agents and comorbidities such as diabetes, pulmonary and cardiac diseases. In particular corticosteroids, even at low doses, are a major risk factor. Due to disease related risk it is difficult to separate the risk deriving from the use of TNF alpha blockers. Data from clinical trials, meta-analysis and national registers are somewhat contradictory. In patients with rheumatoid arthritis on routine follow-up, treatment with TNF alpha blockers seems to carry an increased risk of infections compared to traditional DMARDs but not associated with increased risk of overall serious infection. Physicians should carefully monitor for signs of infection when using TNF alpha blockers, particularly shortly after treatment initiation.
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Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Infecciones Bacterianas
/
Factor de Necrosis Tumoral alfa
/
Antirreumáticos
/
Inmunosupresores
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
It
Revista:
Reumatismo
Año:
2009
Tipo del documento:
Article
País de afiliación:
Italia