Protective effect of stress-induced liver damage by saponin fraction from Codonopsis lanceolata.
Arch Pharm Res
; 32(10): 1441-6, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19898808
ABSTRACT
Saponins are valuable principles found in various herbal medicine with pharmaceutical, cosmetical and nutraceutical merits. In this study, we evaluated the protective role of saponin fraction (Cl-SF), prepared from Codonopsis lanceolata, an ethnopharmacologically famous plant in Korea, China and Japan, on water immersion stress-induced liver damage and radical generation. Cl-SF clearly decreased the up-regulated levels of serum glutamate-oxalacetate transaminase and glutamate-pyruvate-transaminase induced by water-immersed stress conditions. Furthermore, Cl-SF seemed to block the stress-induced radicals. Thus, Griess and DPPH assays revealed that Cl-SF significantly suppressed both radical generation in sodium nitroprusside-treated RAW264.7 cells and nitric oxide production in LPS-treated RAW264.7 cells. Therefore, these results suggest that Cl-SF may be considered as a promising stress-regulatory principle with radical scavenging actions.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Saponinas
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Estrés Psicológico
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Depuradores de Radicales Libres
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Codonopsis
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Hepatopatías
Tipo de estudio:
Etiology_studies
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Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Pharm Res
Año:
2009
Tipo del documento:
Article