Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).

Holden, Matthew T G; Lindsay, Jodi A; Corton, Craig; Quail, Michael A; Cockfield, Joshua D; Pathak, Smriti; Batra, Rahul; Parkhill, Julian; Bentley, Stephen D; Edgeworth, Jonathan D

Holden, Matthew T G; Lindsay, Jodi A; Corton, Craig; Quail, Michael A; Cockfield, Joshua D; Pathak, Smriti; Batra, Rahul; Parkhill, Julian; Bentley, Stephen D; Edgeworth, Jonathan D.

Afiliación

Holden MT; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom. mh3@sanger.ac.uk

J Bacteriol ; 192(3): 888-92, 2010 Feb.

Article en En | MEDLINE | ID: mdl-19948800

ABSTRACT

ABSTRACT

The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions (635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.

Asunto(s)

Farmacorresistencia Bacteriana Múltiple/genética; Genoma Bacteriano/genética; Staphylococcus aureus Resistente a Meticilina/genética; Antibacterianos/farmacología; Antiinfecciosos Locales/farmacología; Metales Pesados/toxicidad; Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos; Modelos Genéticos; Datos de Secuencia Molecular

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genoma Bacteriano / Farmacorresistencia Bacteriana Múltiple / Staphylococcus aureus Resistente a Meticilina Idioma: En Revista: J Bacteriol Año: 2010 Tipo del documento: Article País de afiliación: Reino Unido

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