Genetic commonality of macrolide-resistant group A beta hemolytic streptococcus pharyngeal strains.
Ann Clin Microbiol Antimicrob
; 8: 33, 2009 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-19951439
ABSTRACT
BACKGROUND:
Group A beta hemolytic streptococcus (GABHS) pharyngitis is a common childhood illness. Penicillin remains the gold standard therapy, but macrolides are indicated for the penicillin allergic patient, and are often used for convenience.METHODS:
We conducted a surveillance study of children with pharyngitis and positive streptococcal rapid antigen testing from 10/05 to 10/06 at 2 sites (A & B). Demographics, treatment, and resistance data was collected and compared to previous data from 2002. Erythromycin (EM) resistance was determined by disk diffusion and E-test on 500 isolates. Pulse field gel electrophoresis (PFGE) was performed to measure genetic relatedness of isolates. StatXact version 8 software (Cytel Inc., Cambridge, MA) was utilized to perform Fisher's exact test and exact confidence interval (CI) analysis.RESULTS:
There were no differences in resistance rates or demographic features, with the exception of race, between sites A & B. EM resistance was 0 in 2002, 3.5% in 2005-06 at site A, and 4.5% in 2005-06 at site B. 3/7 and 3/9 had inducible resistance at A and B respectively. 8 isolates had relatedness > or =80%, 5 of which were 88% homologous on PFGE.CONCLUSION:
Community macrolide resistance has increased following increased macrolide use. These results may have treatment implications if use continues to be high.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Estreptocócicas
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Streptococcus pyogenes
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Faringitis
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Macrólidos
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Farmacorresistencia Bacteriana Múltiple
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Antibacterianos
Tipo de estudio:
Observational_studies
Límite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Ann Clin Microbiol Antimicrob
Asunto de la revista:
MICROBIOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos