Measuring attractiveness for abuse of prescription opioids.
Pain Med
; 11(1): 67-80, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-20002325
ABSTRACT
OBJECTIVE:
Prescription opioids are the second most misused/abused drug in the United States behind only marijuana. Recreational prescription opioid users appear to prefer some products over others; however, the extent to which attributes of any particular formulation account for such preferences has yet to be determined. The Opioid Attractiveness Technology Scaling was developed to identify the particular features of a prescription opioid that are relevant to its attractiveness for recreational use, and to use these features to model attractiveness for recreational use of particular prescription opioid formulations.DESIGN:
Four hundred and ninety-one self-reported recreational prescription opioid users identified 43 product features as being relevant to determining whether a product is "attractive" or "unattractive" for recreational use. Average ratings were used to determine appropriate weights to be applied to the features. A factor analysis yielded 10, highly differentiated factors. Five hundred and sixty-four prescription opioid abusers were then asked to rate the extent to which the 43 features identified in Study 1 were relevant to specific prescription opioid products they had used.RESULTS:
Respondents provided an overall preference rating of these products and a model was created. A random intercept model yielded a significant pseudo R(2) of 0.14 (chi-square = 310.02, degrees of freedom [df] = 10, P < 0.001). The model fit least well, albeit significantly, for abusers who preferred to swallow the drug (pseudo R(2) = 0.06; chi-square = 55.52, df = 10, P < 0.001) and best for those who preferred to inject (pseudo R(2) = 0.37; chi-square = 199.34, df = 10, P < 0.001).CONCLUSIONS:
The relevance of the model is discussed along with possible modifications that might allow prediction of "attractiveness" of "abuse deterrent" formulations that have not yet been marketed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Medicamentos bajo Prescripción
/
Analgésicos Opioides
/
Trastornos Relacionados con Opioides
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pain Med
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos