Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independent clines on two continents.
Mol Ecol
; 19(4): 760-74, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-20074316
ABSTRACT
Life history traits are critical components of fitness and frequently reflect adaptive responses to environmental pressures. However, few genes that contribute to natural life history variation have been identified. Insulin signalling mediates the determination of life history traits in many organisms, and single gene manipulation in Drosophila melanogaster suggests that individual genes in the pathway have the potential to produce major effects on these quantitative traits. We evaluated allelic variation at two insulin signalling genes, the Insulin-like Receptor (InR) and its substrate, chico, in natural populations of D. melanogaster. We found different patterns of variation InR shows evidence of positive selection and clines in allele frequency across latitude; chico exhibits neutral patterns of evolution. The clinal patterns at InR are replicated between North America and Australia, showing striking similarity in the distribution of specific alleles and the rate at which allele frequencies change across latitude. Moreover, we identified a polymorphism at InR that appears to be functionally significant and consistent with hypothetical patterns of selection across geography. This polymorphism provides new characterization of genic regions of functionality within InR, and is likely a component in a suite of genes and traits that respond adaptively to climatic variation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Adaptación Fisiológica
/
Proteínas Tirosina Quinasas Receptoras
/
Evolución Molecular
/
Proteínas de Drosophila
/
Drosophila melanogaster
/
Genética de Población
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
País/Región como asunto:
America do norte
/
Oceania
Idioma:
En
Revista:
Mol Ecol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
SAUDE AMBIENTAL
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos