Calcineurin/NFAT signaling in lymphoid malignancies.
Gen Physiol Biophys
; 28 Spec No Focus: F47-54, 2009.
Article
en En
| MEDLINE
| ID: mdl-20093726
Deregulated calcium signaling is observed at different stages of tumorigenic processes. An important signaling pathway activated in response to calcium involves the protein phosphatase calcineurin and NFAT transcriptional factors. We review here recent data that indicate an important role of the calcineurin/NFAT pathway in lymphoma/leukemogenesis and discuss the potential therapeutic implications of these findings.
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Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Leucemia
/
Regulación Leucémica de la Expresión Génica
/
Calcineurina
/
Factores de Transcripción NFATC
/
Linfoma
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Gen Physiol Biophys
Año:
2009
Tipo del documento:
Article
País de afiliación:
Francia