Interactions of antimicrobial peptides with Leishmania and trypanosomes and their functional role in host parasitism.
Exp Parasitol
; 126(3): 397-405, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-20159013
ABSTRACT
Antimicrobial peptides (AMPs) are multifunctional components of the innate systems of both insect and mammalian hosts of the pathogenic trypanosomatids Leishmania and Trypanosoma species. Structurally diverse AMPs from a wide range of organisms have in vitro activity against these parasites acting mainly to disrupt surface-membranes. In some cases AMPs also localize intracellularly to affect calcium levels, mitochondrial function and induce autophagy, necrosis and apoptosis. In this review we discuss the work done in the area of AMP interactions with trypanosomatid protozoa, propose potential targets of AMP activity at the cellular level and discuss how AMPs might influence parasite growth and differentiation in their hosts to determine the outcome of natural infection.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trypanosomatina
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Péptidos Catiónicos Antimicrobianos
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Infecciones por Euglenozoos
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Insectos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Parasitol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos