The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands.
Bioorg Med Chem Lett
; 20(8): 2564-5, 2010 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-20338757
ABSTRACT
A series of pyridylpiperazines was synthesized and analyzed for sigma receptor binding affinity to determine the optimal pyridyl nitrogen position and chain length for the sigma(1) and sigma(2) receptor recognition. The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor sigma(1) receptors, while previously studied (2-pyridyl)piperazines favor sigma(2) receptors.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Receptores sigma
/
Nitrógeno
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos