Ventral striatal plasticity and spatial memory.
Proc Natl Acad Sci U S A
; 107(17): 7945-50, 2010 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-20351272
ABSTRACT
Spatial memory formation is a dynamic process requiring a series of cellular and molecular steps, such as gene expression and protein translation, leading to morphological changes that have been envisaged as the structural bases for the engram. Despite the role suggested for medial temporal lobe plasticity in spatial memory, recent behavioral observations implicate specific components of the striatal complex in spatial information processing. However, the potential occurrence of neural plasticity within this structure after spatial learning has never been investigated. In this study we demonstrate that blockade of cAMP response element binding protein-induced transcription or inhibition of protein synthesis or extracellular proteolytic activity in the ventral striatum impairs long-term spatial memory. These findings demonstrate that, in the ventral striatum, similarly to what happens in the hippocampus, several key molecular events crucial for the expression of neural plasticity are required in the early stages of spatial memory formation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Percepción Espacial
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Ganglios Basales
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Regulación de la Expresión Génica
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Proteína de Unión a Elemento de Respuesta al AMP Cíclico
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Memoria
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Plasticidad Neuronal
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2010
Tipo del documento:
Article
País de afiliación:
Italia