Investigating Association of Three Polymorphisms of Coagulation Factor XIII and Recurrent Pregnancy Loss.
Am J Reprod Immunol
; 64(3): 212-7, 2010 Sep.
Article
en En
| MEDLINE
| ID: mdl-20384622
ABSTRACT
PROBLEM:
among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of coagulation factor XIII (FXIII) gene. We performed a case-control study on the association between three polymorphisms of factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women. METHOD OF STUDY DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups.RESULTS:
the prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P <0.001 and P < 0.001), respectively. The two latter polymorphisms are associated with RPL in Iranian women and increase the risk of RPL. A correlation was also found between FXIII A614T and FXIII C1694T polymorphisms (P < 0.001).CONCLUSION:
we suggest the evaluation of FXIII A614T and FXIII C1694T polymorphisms in women with RPL.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factor XIII
/
Aborto Habitual
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
Am J Reprod Immunol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Irán