[Coronary reserve determination by intracoronary papaverine: effects of various doses on coronary circulation and hemodynamics]. / Bestimmung der Koronarreserve durch intrakoronare Papaverinapplikation: Auswirkungen unterschiedlicher Dosen auf Koronarfluss and Hämodynamik.
Z Gesamte Inn Med
; 46(1-2): 15-7, 1991.
Article
en De
| MEDLINE
| ID: mdl-2038868
ABSTRACT
In 40 male coronary patients during heart catheterization the coronary flow reserve was investigated by continuous thermodilution in the coronary sinus after intracoronary papaverine application. Simultaneously a number of heart function parameters were recorded. Already the lowest dosage of papaverine (5 mg) was able to induce a maximal flow acceleration. Higher dosages were accompanied with haemodynamic side effects (increase of heart rate and left ventricular end-diastolic pressure, decrease of left ventricular systolic pressure, appearance of myocardial ischemia) without further increase of coronary flow. After at most 5 minutes time the papaverine effects completely disappeared. In conclusion, a safe, short-lasting and repeatable determination of the coronary flow reserve (for instance during PTCA) proved to be possible after intracoronary papaverine injection in low dosages (5 mg).
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Banco de datos:
MEDLINE
Asunto principal:
Papaverina
/
Cateterismo Cardíaco
/
Circulación Coronaria
/
Enfermedad Coronaria
/
Hemodinámica
Límite:
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Z Gesamte Inn Med
Año:
1991
Tipo del documento:
Article