Genome remodelling in a basal-like breast cancer metastasis and xenograft.
Nature
; 464(7291): 999-1005, 2010 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-20393555
ABSTRACT
Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples from an African-American patient with basal-like breast cancer peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The metastasis contained two de novo mutations and a large deletion not present in the primary tumour, and was significantly enriched for 20 shared mutations. The xenograft retained all primary tumour mutations and displayed a mutation enrichment pattern that resembled the metastasis. Two overlapping large deletions, encompassing CTNNA1, were present in all three tumour samples. The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within the primary tumour.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Neoplasias de la Mama
/
Genoma Humano
/
Mutación
/
Trasplante de Neoplasias
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Nature
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos