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An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity.
Baker, James R; Hothersall, J Daniel; Fitzmaurice, Richard J; Tucknott, Matthew; Vinter, Andy; Tinker, Andrew; Caddick, Stephen.
Afiliación
  • Baker JR; Department of Chemistry, University College London, 20 Gordon St, London, UK. j.r.baker@ucl.ac.uk
Chem Commun (Camb) ; 46(22): 3953-4, 2010 Jun 14.
Article en En | MEDLINE | ID: mdl-20431838
A highly efficient, practical and flexible two-step asymmetric synthesis of the beta(2)-selective beta-blocker ICI 118,551 is reported, allowing an unambiguous determination of the dependency of biological activity with optical activity, revealing the S,S-enantiomer to be the most potent.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Propanolaminas / Antagonistas Adrenérgicos beta Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2010 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Propanolaminas / Antagonistas Adrenérgicos beta Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2010 Tipo del documento: Article