Effects of keratinocyte growth factor-2 on corneal epithelial wound healing in a rabbit model of carbon dioxide laser injury.
Biol Pharm Bull
; 33(6): 971-6, 2010.
Article
en En
| MEDLINE
| ID: mdl-20522961
ABSTRACT
Keratinocyte growth factor-2 (KGF-2), also called fibroblast growth factor-10 (FGF-10), is a member of the fibroblast growth factor family. It plays a critical role in epithelial development and exerts its biological activities in a paracrine manner on the receptor FGFR2-IIIb. This study examined the function of topically applied KGF-2 in vivo on wound healing using a CO(2) laser, corneal epithelial wounded, rabbit model. Topically applied 25 microg/ml KGF-2 accelerated corneal epithelial wound healing, in contrast to the control, and reduced inflammation, stromal edema, and fibrosis. In addition, this factor also exhibited significant inhibition of corneal neovascularization. KGF-2 appears to be another important growth factor in the regulation of corneal epithelial wound healing.
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Banco de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Epitelio Corneal
/
Inhibidores de la Angiogénesis
/
Factor 10 de Crecimiento de Fibroblastos
/
Antiinflamatorios
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Biol Pharm Bull
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
China