Longevity is not influenced by prenatal programming of body size.
Aging Cell
; 9(4): 647-9, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20550518
ABSTRACT
Insulin-like growth factor (IGF) signaling is essential for achieving optimal body size during fetal development, whereas, in the adult, IGFs are associated with aging and age-related diseases. However, it is unclear as to what extent lifespan is influenced by events that occur during development. Here, we provide direct evidence that the exceptional longevity of mice with altered IGF signaling is not linked to prenatal programming of body size. Mice null for pregnancy-associated plasma protein-A (PAPP-A), an IGF-binding protein proteinase that increases local IGF bioavailability, are 60-70% the size of their wild-type littermates at birth and have extended median and maximum lifespan of 30-40%. In this study, PAPP-A(-/-) mice whose body size was normalized during fetal development through disruption of IgfII imprinting did not lose their longevity advantage. Adult-specific moderation of IGF signaling through PAPP-A inhibition may present a unique opportunity to improve lifespan without affecting important aspects of early life physiology.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tamaño Corporal
/
Desarrollo Embrionario
/
Longevidad
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Aging Cell
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos