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Frequency of respiratory deterioration after immunisation in preterm infants.
Hacking, Douglas F; Davis, Peter G; Wong, Ester; Wheeler, Kevin; McVernon, Jodie.
Afiliación
  • Hacking DF; Division of Newborn Services, The Royal Women's Hospital, 20 Flemington Road, Parkville, Vic. 3052, Australia. doug.hacking@thewomens.org.au
J Paediatr Child Health ; 46(12): 742-8, 2010 Dec.
Article en En | MEDLINE | ID: mdl-20825611
AIM: To determine the relationship between the initiation of respiratory support and the first routine immunisation of neonates at 2 months of age during primary hospitalisation. METHODS: An historical cohort study design was used to study the neonatal factors associated with the initiation of respiratory support within 7 days of immunisation in a cohort of 7629 preterm and term infants admitted to the Neonatal Unit of the Royal Women's Hospital between 2001 and 2008. RESULTS: The 411 infants who received their first immunisations in hospital were both very preterm and of extremely low birth weight (ELBW, below 1000 g). Twenty-two infants experienced post-immunisation apnoea of sufficient severity to warrant the initiation of either intermittent positive pressure ventilation (two cases) or continuous positive airway pressure (20 cases). Infants exhibiting a respiratory deterioration following immunisation had a higher incidence of previous septicaemia (Odds ratio 2.5, 95% confidence interval 1.0, 6.1; P = 0.04) and received CPAP for a longer period prior to vaccination (P = 0.03). CONCLUSION: Apnoea following immunisation may be an aetiological factor in the requirement of respiratory support in a small number of preterm, ELBW infants particularly those with significant lung disease and those who have previously experienced septicaemia.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Insuficiencia Respiratoria / Inmunización / Nacimiento Prematuro Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans / Infant / Newborn País/Región como asunto: Oceania Idioma: En Revista: J Paediatr Child Health Asunto de la revista: PEDIATRIA Año: 2010 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Insuficiencia Respiratoria / Inmunización / Nacimiento Prematuro Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans / Infant / Newborn País/Región como asunto: Oceania Idioma: En Revista: J Paediatr Child Health Asunto de la revista: PEDIATRIA Año: 2010 Tipo del documento: Article País de afiliación: Australia