Streaming instability in growing cell populations.
Phys Rev Lett
; 104(20): 208101, 2010 May 21.
Article
en En
| MEDLINE
| ID: mdl-20867071
ABSTRACT
Flows of cells growing as a quasimonolayer in a confined space can exhibit streaming, with narrow streams of fast-moving cells flowing around clusters of slowly moving cells. We observed and analyzed this phenomenon experimentally for E. coli bacteria proliferating in a microfluidic cell trap using time-lapse microscopy. We also performed continuum modeling and discrete-element simulations to elucidate the mechanism behind the streaming instability. Our analysis demonstrates that streaming can be explained by the interplay between the slow adaptation of a cell to its local microenvironment and its mobility due to changes of cell-substrate contact forces.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Técnicas de Cultivo de Célula
/
Escherichia coli
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Phys Rev Lett
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos