Fine mapping of a quantitative trait locus for osteochondrosis on horse chromosome 2.
Anim Genet
; 41 Suppl 2: 87-90, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-21070281
ABSTRACT
In this study, we refine a quantitative trait locus for equine osteochondrosis (OC) on horse chromosome (ECA) 2 to a genome-wide significant interval at 20.08-30.94 Mb. The marker set contained 27 newly developed microsatellites equidistantly distributed over ECA2 and 44 nucleotide polymorphisms, located in 16 positional candidate genes for OC. Genotyping was performed in 211 Hanoverian horses from 14 paternal half-sib groups. A NCDN-associated SNP and haplotype were significantly associated with OC in fetlock and/or hock joints. This study is a further step towards the identification of genes responsible for OC in horses.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sitios de Carácter Cuantitativo
/
Osteocondrosis
/
Enfermedades de los Caballos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Anim Genet
Asunto de la revista:
GENETICA
/
MEDICINA VETERINARIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania