A comparison of gray matter density in restless legs syndrome patients and matched controls using voxel-based morphometry.
J Neuroimaging
; 22(1): 28-32, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-21091816
ABSTRACT
BACKGROUND:
Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have examined structural differences between the brains of RLS patients and healthy controls, using voxel-based morphometry (VBM). All 4 studies have provided different results.METHODS:
Optimized VBM was used to search for structural differences in gray matter density. Sixteen RLS patients naïve to dopaminergic drugs and 16 age- and sex-matched controls received structural T1-weighted MR scans. Structural data were analyzed using FSL-VBM.RESULTS:
No difference in gray matter density was detected between the two groups (voxel-wisesignificance:
no significant voxels at P= .89 (whole brain Family Wise Error (FWE) corrected); no significant voxels at P < .05 (whole brain False Discovery Rate (FDR) corrected; smallest achievable FDR threshold .99). CONCLUSION/DISCUSSION:
The present study did not replicate (confirm) previous findings of structural brain changes in RLS, but instead supported the findings of a recent study showing a lack of gray matter alteration in an elderly RLS population. More specifically, the results do not support neuronal loss as an underlying disease mechanism in RLS. Potential limitations in the application of VBM are also discussed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de las Piernas Inquietas
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Encéfalo
/
Imagen por Resonancia Magnética
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Interpretación de Imagen Asistida por Computador
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Imagenología Tridimensional
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Neuronas
Tipo de estudio:
Diagnostic_studies
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Observational_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neuroimaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
NEUROLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido