Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae.
Arch Environ Contam Toxicol
; 61(2): 300-10, 2011 Aug.
Article
en En
| MEDLINE
| ID: mdl-21110015
ABSTRACT
Endocrine-disrupting chemicals can influence the hypothalamus-pituitary-gonad axis and possibly affect reproduction in vertebrates. We analyzed the effect of 30-day endosulfan (ES) exposure in sexually undifferentiated larvae of the cichlid fish Cichlasoma dimerus. The number, area, mean cytoplasmic and nuclear diameter, and mean cytoplasmic optical density of gonadotropin-releasing hormone (GnRH) I, II, and III immunoreactive (ir-) neurons and ß follicle-stimulating hormone (ßFSH) ir-cells were measured. Animals exposed to the highest ES concentration (0.1 µg/l) showed a decrease in GnRH I nucleus/cytoplasm area ratio upon exposure. Nuclear area and mean nuclear diameter of ßFSH ir-cells was higher in ES treated fish. ßFSH nucleus/cytoplasm area ratio was high in exposed animals, and animals exposed to 0.1 µg/l ES showed smaller mean cytoplasmic optical density. These findings suggest that ES affects GnRH I and ßFSH protein synthesis/release. However, these responses seem to be insufficient to affect gonadal differentiation at this stage of development.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Gonadotropina
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Cíclidos
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Endosulfano
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Exposición a Riesgos Ambientales
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Hidrocarburos Clorados
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Insecticidas
Límite:
Animals
Idioma:
En
Revista:
Arch Environ Contam Toxicol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Argentina