A kinetic model for human blood concentrations of gaseous halocarbon fire-extinguishing agents.
Inhal Toxicol
; 22(14): 1151-61, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-21110781
ABSTRACT
A simple kinetic model for calculating the blood concentration history of humans exposed to time-varying concentrations of gaseous, halocarbon fire-extinguishing agents is described. The kinetic model was developed to extend experimental physiologically based pharmacokinetic (PBPK) models for arterial blood concentration of halocarbons, obtained from constant concentration exposure of dogs to time-varying exposure conditions for humans. In the present work, the simplified kinetic model was calibrated using published PBPK-derived arterial concentration histories for constant concentration exposure to several common fire-extinguishing agents. The calibrated kinetic model was then used to predict the blood concentration histories of humans exposed to time-varying concentrations of these fire-extinguishing agents in ventilated compartments and the results were compared with PBPK-derived data for the agents. It was found that the properly calibrated kinetic model predicts human arterial blood concentration histories for time-varying exposures as well as the PBPK models. Consequently, the kinetic model represents an economical methodology for calculating safe human exposure limits for time-varying concentrations of gaseous halocarbon fire-extinguishing agents when only PBPK-derived human arterial blood concentration histories for constant exposure conditions are available.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Exposición por Inhalación
/
Sistemas de Extinción de Incendios
/
Hidrocarburos Halogenados
/
Modelos Biológicos
Tipo de estudio:
Health_economic_evaluation
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Inhal Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos