Inducible production of macrophage colony-stimulating factor (CSF-1) by malignant and normal human T cells.
Leukemia
; 4(6): 411-4, 1990 Jun.
Article
en En
| MEDLINE
| ID: mdl-2113600
ABSTRACT
The CEM-ON malignant T cell line and long-term cultured normal T cells can be induced to release CSF-1 in their culture supernatants. Chemical inducers (PMA + A23187) and, more interestingly, cytokines (tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha)), as well as physiological (antigen + IL-2) or specific (anti-CD3 + IL-2 or PMA) stimuli, lead to rapid transient colony-stimulating factor-1 (CSF-1) gene expression and production of biologically active CSF-1. These data suggest that CSF-1 may play a role in the early phases of immune response.
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Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Leucemia de Células T
/
Factores Estimulantes de Colonias
Límite:
Humans
Idioma:
En
Revista:
Leukemia
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
1990
Tipo del documento:
Article
País de afiliación:
Francia