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Forming spirocyclohexadienone-oxocarbenium cation species in the biomimetic synthesis of amomols.
Traoré, Mariam; Maynadier, Marjorie; Souard, Florence; Choisnard, Luc; Vial, Henri; Wong, Yung-Sing.
Afiliación
  • Traoré M; Département de Pharmacochimie Moléculaire, Université Joseph Fourier-Grenoble 1, CNRS UMR 5063, CNRS ICMG FR 2607, bâtiment André Rassat, 470 rue de la Chimie, F-38041 Grenoble Cedex 9, France.
J Org Chem ; 76(5): 1409-17, 2011 Mar 04.
Article en En | MEDLINE | ID: mdl-21250723
The oxidation of appropriate 2-(4-hydroxyphenyl)ethyl ketones gives direct access to amomols by means of the formation of a transient spirocyclohexadienone-oxocarbenium ion that is intermolecularly intercepted by an alcohol. Furthermore, homochiral amomols and other new analogues were synthesized for the first time and were biologically evaluated on Plasmodium falciparum.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos de Espiro / Ciclohexanos / Biomimética / Furanos / Cetonas Idioma: En Revista: J Org Chem Año: 2011 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos de Espiro / Ciclohexanos / Biomimética / Furanos / Cetonas Idioma: En Revista: J Org Chem Año: 2011 Tipo del documento: Article País de afiliación: Francia