Increase in body size is associated with an increased incidence of advanced adenomatous colon polyps in male veteran patients.
Digestion
; 83(4): 288-90, 2011.
Article
en En
| MEDLINE
| ID: mdl-21282954
ABSTRACT
BACKGROUND/AIMS:
Our aim was to determine how weight change influences the development of advanced adenomas.METHODS:
We performed a retrospective study of patients with adenomatous polyps (APs) on an index colonoscopy, and who also had a follow-up colonoscopy 3-5 years later. APs were evaluated for advanced features (i.e. size ≥1 cm in diameter and/or villous component and/or high-grade dysplasia). Patients were divided into 2 groups those with no change or a reduction in their body mass index (BMI) during the interval between colonoscopies and those with an increase in BMI during the interval between colonoscopies.RESULTS:
925 patients with a history of APs were identified. Univariate analysis showed that patients with an increase in BMI had more advanced APs (28 vs. 23%, p = 0.04), and a larger mean AP size (8.0 vs. 6.8 mm, p = 0.03) than those with a no change or decreased BMI. Multiple logistic regression analysis revealed that a decrease in BMI between colonoscopies was associated with a significantly reduced risk of developing advanced APs (OR 0.4, 95% CI 0.37-0.5, p < 0.05).CONCLUSIONS:
An increase in weight in male veterans appears to be strongly associated with the development of clinically advanced AP lesions, even after adjustment for other known polyp risk factors.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Colon
/
Pólipos Adenomatosos
/
Tamaño Corporal
/
Salud de los Veteranos
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Digestion
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos