Correlation between serum immunoglobulin G and hearing threshold among elderly subjects with age-related hearing loss.
ORL J Otorhinolaryngol Relat Spec
; 73(2): 88-92, 2011.
Article
en En
| MEDLINE
| ID: mdl-21304224
ABSTRACT
BACKGROUND AND PURPOSE:
This study was based on the hypothesis that suboptimal immune response and low serum immunoglobulin G (IgG) may predispose to age-related hearing loss (ARHL), and the objective was to determine the serum levels of IgG and hearing thresholds of apparently healthy elderly subjects and assess their correlation.METHOD:
This prospective study involved 126 participants ≥ 60 years old who were found to be free of any medical conditions. Pure-tone averages for both the speech (500-2,000 Hz) and high frequencies (3,000-8,000 Hz) and serum IgG levels were determined. Using 30 dB as cut-off for hearing loss, the correlation with serum IgG was assessed.RESULTS:
There were 59 males and 67 females with a mean age ± SD of 67.0 ± 2.7 years. Speech frequency hearing loss was seen in 30.2%, while high-frequency hearing loss accounted for 74.6%. In the speech frequencies, the mean ± SD of serum IgG among subjects with normal hearing was 11.3 ± 3.9 g/l, while among those with hearing loss it was 8.3 ± 3.3 g/l (p = 0.01). In the high frequencies, the mean ± SD values of serum IgG among the subjects with normal hearing was 11.1 ± 2.3 g/l, while among those with hearing loss it was 8.7 ± 1.9 g/l (p = 0.01).CONCLUSION:
Low serum IgG may be a contributory factor to the development of ARHL among the elderly. However, a longitudinal study involving intervention with immunoglobulin supplementation may further confirm this role.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Presbiacusia
/
Umbral Auditivo
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Inmunoglobulina G
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
ORL J Otorhinolaryngol Relat Spec
Año:
2011
Tipo del documento:
Article
País de afiliación:
Nigeria