RNase E action at a distance: degradation of target mRNAs mediated by an Hfq-binding small RNA in bacteria.
Genes Dev
; 25(4): 294-8, 2011 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-21325130
A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prévost and colleagues (pp. 385-396) demonstrate by using the well-characterized sRNA RyhB that RNase E cleavage at sites distal from the pairing region triggers degradation of target mRNAs. The study has provided an important insight into the initial events of sRNA-induced degradation of target mRNAs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Bacterias
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Estabilidad del ARN
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Proteínas de Escherichia coli
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Proteína de Factor 1 del Huésped
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ARN Interferente Pequeño
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Endorribonucleasas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Genes Dev
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón