Co-administration of intravesical bacillus Calmette-Guérin and interferon α-2B as first line in treating superficial transitional cell carcinoma of the urinary bladder.
BJU Int
; 108(7): 1115-8, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21332904
ABSTRACT
OBJECTIVE:
⢠To evaluate the efficacy and toxicity of the combination of bacillus Calmette-Guérin (BCG) and interferon α-2B (IFNα-2B) in treating superficial bladder cancer (SBC). The mentioned combination has shown synergism in pre-clinical studies. PATIENTS ANDMETHODS:
⢠The present study is a single-arm, open-label, single-institution prospective trial. Patients with Ta, T1 or in situ carcinoma and no previous intravesical therapy were included between July 2002 and June 2009. ⢠Patients were treated with weekly intravesical instillation of 27 mg of BCG mixed with 10 million units (MU) of IFNα-2B for six consecutive weeks followed by 3-weekly booster instillations at 3 months if there was no recurrence. ⢠The primary endpoint was disease recurrence. Secondary endpoints were disease progression and toxicity. ⢠Patients were followed-up with cystoscopy and urine cytology every 3 months.RESULTS:
⢠In all, 50 patients were included. ⢠At a median follow-up of 55.8 months, 31 (62%) patients were recurrence-free. ⢠Progression to muscle invasion occurred in two (4%) and metastasis occurred in two (4%) patients. ⢠Treatment was well tolerated, with grade III dysuria and frequency occurring in 18 and 14% of patients, respectively, and with 74% of patients being able to complete the maintenance dosage.CONCLUSION:
⢠The combination of BCG and IFNα-2B in the patient population with SBC has similar efficacy and toxicity to BCG monotherapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
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Vacuna BCG
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Carcinoma de Células Transicionales
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Adyuvantes Inmunológicos
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Interferón-alfa
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Antineoplásicos
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BJU Int
Asunto de la revista:
UROLOGIA
Año:
2011
Tipo del documento:
Article